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KMID : 1004820140150040170
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Journal of Biomedical Research
2014 Volume.15 No. 4 p.170 ~ p.175
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Protective effect of halophyte Salsola komarovi Iljin against gastric ulcer Induced by alcohol treatment in rats
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Hong Sun-Hwa
Lee Hyun-A
Lee Yun-Seong
Kim Dong-Woo
Oh Gi-Wook
Woo Ji-Wan
Cho Yak-Dol
Jeong Jae-Hyeok
Kim Ok-Jin
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Abstract
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Salsola komarovi Iljin is a halophyte and herbaceous annual native to the sand dunes and beaches of Japan, northern China, Sakhalin, and Korea. The plants have been known as an ecologically important species for enhancing formation of sand dunes in Korea. The purpose of this study was to examine the anti-gastric ulcer effect of Salsola komarovi Iljin halophyte in an HClethanol-induced gastritis model. SD rats (7-weeksold) were divided into normal (I, n=10), control (II,
60% HCl-ethanol + water, n=10), 60% HCl-ethanol + Ranitidine 300 mg/kg (III, n=10), 60% HCl-ethanol + Salicornia herbacea L. 500 mg/kg (IV, n=10), 60% HCl-ethanol + 50% alcohol extract of Salsola komarovi Iljin 500 mg/kg (V, n=10), and 60% HCl-ethanol + water extract of Salsola komarovi Iljin 500 mg/kg (VI, n=10) groups. Salsola komarovi Iljin significantly suppressed gastric lesions and ulcers in the 60% HClethanol-induced gastric model. Especially, 500 mg/kg of 50% alcohol extract of Salsola komarovi Iljin showed significant inhibitory effects against gastritis. Especially, 50% alcohol extract of Salsola komarovi Iljin 500 mg/kg showed a significantly inhibitory effect, which was more potent than that of 300 mg/kg of
Ranitidine. In histopathological analysis of the animal model, Salsola komarovi Iljin attenuated gastric ulcer formation. Our results suggest that Salsola komaroviIljin has inhibitory effects against gastritis and gastric ulcers and could be developed as a new anti-gastric ulcer agent.
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KEYWORD
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Salsola Komarovi Iljin, halophyte, anti-gastritis, anti-gastric ulcer, gastric mucosal damage
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